Past Pilot & Feasibility Award Winners
View the list of Pilot & Feasibility awarded projects since 1986
| Principal Investigator | Applicant Institution | Dates of Award | Pilot Project Title |
|---|---|---|---|
| Daniel Zeve, MD, PhD | Boston Children’s Hospital | 4/2021 - 3/2023 | Use of human enteroids/organoids to induce K and L enteroendocrine cells that appropriately respond to nutrients in vitro and in vivo |
| Ismail Sayed, PhD | Beth Israel Deaconess Med Ctr | 4/2021 - 3/2023 | Effects of novel lipids on on the NLRP3 inflammasome and impact on diabetogenesis in NOD model |
| Linus Tzu-Yen Tsai MD, PhD | Beth Israel Deaconess Med Ctr | 7/2020 - 6/2022 | The role of interferon regulatory factors in tanycytes during HFD-induced inflammation, obesity and glucose dysregulation |
| Matthew Lynes, PhD | Joslin Diabetes Center | 7/2020 - 6/2022 | Genetic determinants of 12, 13-diHOME biosynthesis in human obesity |
| Aleksandar Kostic, PhD | Joslin Diabetes Center | 5/2019 - 4/2021 | Designing and testing novel probiotic strategies to curtail glycemic excursion |
| Sirano Dhe-Paganon, PhD | Dana-Farber Cancer Institute | 5/2019 - 4/2021 | Structural basis of XOR activation in obesity and metabolic syndrome |
| Amy Wagers, PhD | Joslin Diabetes Center | 4/2018 - 3/2020 | Hematologic mutations as potential predictors of diabetic complications |
| Stephen Liberles, PhD | Harvard Medical School | 4/2018 - 3/2020 | The impact of vagal nutrient-sensing neurons on systemic metabolism |
| Eyal Dassau, PhD | Harvard School of Engineering and Applied Sciences | 1/2018 - 12/2019 | Can technology improve self-care in youth with Type-1 Diabetes? |
| Cristina Aguayo-Mazzucato, MD, PhD | Joslin Diabetes Center | 1/2018 - 12/2019 | Induction of beta-cell senescence by high-fat diet and implications for diabetes |
| Sarah Lessard, PhD | Joslin Diabetes Center | 1/2017 - 12/2018 | Mechanisms of exercise resistance in diabetes |
| Thomas McElrath, MD, PhD | Brigham and Women's Hospital | 1/2017 - 12/2018 | Circulating SerpinB1 and vulnerability to gestational diabetes |
| Ashley Vernon, MD | Brigham and Women's Hospital | 1/2016 - 12/2017 | Human adipose tissue microbiome in type 2 diabetes |
| Peng Yi, PhD | Joslin Diabetes Center | 1/2016 - 12/2017 | A CRISPR-Cas9 screening for genes regulating pancreatic beta cell proliferation |
| Lijun Sun, PhD | Beth Israel Deaconess Med Ctr | 1/2015 - 12/2016 | Targeting activated mast cells in diabetic foot ulcers |
| Norbert Perrimon, PhD | Harvard Medical School | 1/2015 - 12/2016 | Activin regulation of glucagon action: a novel therapeutic opportunity for type 2 diabetes |
| Thomas Serwold, PhD | Joslin Diabetes Center | 1/2015 - 12/2016 | Antigen spreading in the initiation of type 1 diabetes |
| Jongsoon Lee, PhD | Joslin Diabetes Center | 1/2014 - 12/2015 | The role of adipose tissue foam cells in lipid homeostasis and inflammation |
| F.M. Fisher, PhD | Beth Israel Deaconess Med Ctr | 1/2014 - 12/2015 | FGF21 induced white adipose tissue browning |
| Stephan Kissler, PhD | Joslin Diabetes Center | 1/2013 - 12/2014 | How TAGAP variation impacts T cell migration in type 1 diabetes |
| Aaron Cypess, MD, PhD | Joslin Diabetes Center | 1/2013 - 12/2014 | β3-Adrenergic receptor agonists on human brown adipose tissue |
| Monika Niewczas, MD, PhD | Joslin Diabetes Center | 8/2011 - 7/2013 | Regulation of circulating sTNF receptors in diabetes |
| Jason Gaglia, MD | Joslin Diabetes Center | 8/2011 - 7/2013 | Imaging Islet-Antigen reactive peripheral T cells |
| Janice Zabolotny, PhD | Beth Israel Deaconess Med Ctr | 8/2010 - 7/2012 | Mechanisms to improve wound healing in diabetes |
| Jennifer Sun, MD | Joslin Diabetes Center | 8/2010 - 7/2012 | Predicting treatment response in diabetic macular edema |
| Raul Mostoslavsky, MD, PhD | Mass. General Hospital | 8/2009 - 7/2011 | SIRT6 controls glucose homeostasis |
| Libin Liu, PhD | Joslin Diabetes Center | 8/2009 - 7/2011 | Macrophage Cpe causes obesity in fatty fa/fa mice |
| Ho-Jin Koh, PhD | Joslin Diabetes Center | 8/2009 - 7/2011 | TRB3 modulates glucose-lipid metabolism in skeletal muscle |
| Sudha Biddinger, MD, PhD | Boston Children's Hospital | 8/2009 - 7/2011 | Defects in insulin signaling in the metabolic syndrome |
| Michael Zeisberg, MD | Beth Israel Deaconess Med Ctr | 8/2008 - 7/2009 | Epigenetics of diabetic nephropathy |
| Giulio Romeo, MD | Joslin Diabetes Center | 8/2008 - 7/2010 | Profilin-1 in diet-induced insulin resistance |
| Josef Michael Kurtz, PhD | Mass. General Hospital | 9/2008 - 8/2010 | Characterization of diabetogenic CD4 cells in T1D |
| Lloyd Paul Aiello, MD, PhD | Joslin Diabetes Center | 8/2008 - 7/2010 | Why do retinal vessels break through the ILM in PDR? |
| Christian Rask-Madsen, MD, PhD | Joslin Diabetes Center | 8/2007 - 7/2009 | Role of PKC in diabetic retinopathy |
| Erin Kershaw, MD | Beth Israel Deaconess Med Ctr | 8/2007 - 7/2009 | In Vivo role of adiponutrin in metabolic and energy homeostasis |
| Amy Wagers, PhD | Joslin Diabetes Center | 8/2006 - 7/2008 | Circulating factors in diabetic wound healing |
| Alan Davidson, PhD | Mass General Hospital | 8/2006 - 7/2008 | Zebrafish model of diabetic nephropathy |
| Gail Musen, PhD | Joslin Diabetes Center | 8/2005 - 7/2007 | Functional correlates of gray matter changes in diabetes |
| Timothy Graham, MD, PhD | Beth Israel Deaconess Med Ctr | 8/2005 - 7/2007 | RBP4 & maternal transmission of insulin resistance |
| Edward Feener, PhD | Joslin Diabetes Center | 3/2005 - 2/2006 | Ion Trap LC-MS/MS quantitation of peptides in vitreous humor |
| Shannon Turley, PhD | Dana-Farber Cancer Institute | 8/2004 - 7/2006 | The capture of dying beta cells by dendritic cells |
| Medha Munshi, MD | Joslin Diabetes Center | 8/2004 - 7/2008 | Executive dysfunction in older diabetic patients |
| Jongsoon Lee, PhD | Joslin Diabetes Center | 8/2003 - 7/2005 | Role of GSK3b in fat cell differentiation |
| Sirano Dhe-Paganon, PhD | Joslin Diabetes Center | 8/2003 - 7/2005 | Structural determination of PKC and drug mapping |
| Gail Adler, MD, PhD | Brigham and Women's Hospital | 8/2003 - 7/2005 | Aldosterone and vascular disease in diabetes |
| Rohit Kulkarni, MD, PhD | Joslin Diabetes Center | 8/2002 - 7/2004 | Role of insulin receptors in islet alpha cell function |
| Young-Bum Kim, PhD | Beth Israel Deaconess Med Ctr | 8/2002 - 7/2004 | The potential role of the long-form of the leptin receptor in adipocytes |
| Mark Anderson, MD, PhD | Joslin Diabetes Center | 8/2002 - 8/2003 | Genetic analysis of the AIRE gene in type 1 DM |
| Lucia Rameh, PhD | Beth Israel Deaconess Med Ctr | 6/2000 - 5/2002 | PIP4kllb role in glucose homeostasis and insulin resistance |
| Tihamer Orban, MD | Joslin Diabetes Center | 6/2000 - 5/2002 | Autoantigen vaccination in human type 1 diabetes mellitus |
| Alessandro Doria, MD, PhD | Joslin Diabetes Center | 6/2000 - 5/2002 | Functional complementation of insulin-resistance genes |
| Deborah Burks, PhD | Joslin Diabetes Center | 10/1999 - 9/2000 | The Role of IRS-2 in endocrine vascular function |
| Christian Bjorbaek, PhD | Beth Israel Deaconess Med Ctr | 10/1999 - 9/2001 | Role of PIAS proteins in Leptin signaling and Leptin resistance |
| Robert Stanton, MD | Joslin Diabetes Center | 10/1998 - 9/2000 | Glucose 6-P dehydrogenase and apoptosis in diabetes |
| Martin Myers, MD, PhD | Joslin Diabetes Center | 12/1997 - 11/1999 | Role of Leptin receptor signaling pathways in physiology |
| Mary Elizabeth Patti, MD | Joslin Diabetes Center | 12/1996 - 11/1998 | Novel mechanisms for nutrient regulation of insulin action |
| Arun Sharma, PhD | Joslin Diabetes Center | 12/1996 - 11/1998 | Cloning of an insulin gene transcription factor, RIPE3b1 |
| Lori Laffel, MD | Joslin Diabetes Center | 1/1996 - 11/1996 | Pregnancy and diabetic nephropathy in women with IDDM |
| Elefteria Maratos-Flier, MD | Joslin Diabetes Center | 12/1995 - 11/1997 | MCH: A novel regulator of feeding behavior |
| Bentley Cheatham, PhD | Joslin Diabetes Center | 9/1995 - 11/1996 | Role of Rab proteins in Glut4 translocation |
| Alessandro Doria, MD, PhD | Joslin Diabetes Center | 1994 - 1996 | Screening for mutations at the Rad locus, a candidate gene for NIDDM |
| Gokhan Hotamisligil, MD, PhD | Harvard School of Public Health | 1995 - 1997 | Role of TNF receptors in obesity and insulin resistance |
| Laurie Goodyear, PhD | Joslin Diabetes Center | 1993 - 1995 | Molecular mechanisms of skeletal muscle insulin resistance |
| Lloyd-Paul Aiello, MD, PhD | Joslin Diabetes Center | 1993 - 1995 | Role of vascular endothelial growth factor in diabetic retinopathy |
| Mary Loeken, PhD | Joslin Diabetes Center | 1993 - 1995 | The search for genes that cause diabetic embryopathy |
| Myra Lipes, MD | Joslin Diabetes Center | 1992 - 1994 | Genetic dissection of T cell requirements for autoimmune diabetes |
| Peter Arvan, MD, PhD | Beth Israel Deaconess Med Ctr | 1991 - 1993 | Secretory protein targeting in pancreatic B-cells |
| Heimo Riedel, PhD | Joslin Diabetes Center | 1991 - 1993 | A genetic screen for receptor-substrate/ligand binding |
| Steven Shoelson, MD, PhD | Joslin Diabetes Center | 1991 - 1992 | YMXM motifs, SH2 domains and insulin action |
| Christopher Rhodes, PhD | Joslin Diabetes Center | 1990 - 1992 | The endopeptidic processing of insulin receptor |
| Barbara Anderson, William Polonsky PhD, PhD | Joslin Diabetes Center | 1990 - 1991 | Clinical and subclinical eating disorders in female patients with diabetes |
| Barbara Widom, MD | Joslin Diabetes Center | 1989 - 1990 | Mechanism of weight gain during intensive insulin therapy |
| Barry Goldstein, MD, PhD | Joslin Diabetes Center | 1989 - 1991 | Molecular cloning of the rat insulin receptor cDNA |
| Masakazu Hattori, MD, PhD | Joslin Diabetes Center | 1988 - 1990 | Islet T-lymphocyte clones of type 1 diabetes patients |
| Mary Loeken, PhD | Joslin Diabetes Center | 1988 - 1990 | Transcriptional control by insulin during myogenesis |
| Raymonde Dumont (née Herskowitz) M.D. | Joslin Diabetes Center | 1987 - 1988 | Transient hyperglycemia in children |
| Steve Rabinowe, MD | Joslin Diabetes Center | 1987 - 1988 | The presence and significance of antiadrenal medullary antibodies in type 1 diabetes mellitus |
| Morris White, PhD | Joslin Diabetes Center | 1987 - 1989 | Relation between the insulin receptor and pp 60src in hepatoma cells |
| Elefteria Maratos-Flier, MD | Beth Israel Deaconess Med Ctr | 1987 - 1989 | Effect of reovirus infection on gene expression |
| Richard Jackson, MD | Joslin Diabetes Center | 1986 - 1987 | T cell receptor and MHC genes |
| Albert Edge, PhD | Joslin Diabetes Center | 1986 - 1987 | Studies on carbohydrates of the insulin receptor |
